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However, evidence for the efficacy and safety of using multiple antipsychotic medications is limited, and risk for drug interactions, noncompliance, and medication errors is increased.

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Expert review of hepatotoxicity published in 1999; no mention of mirtazapine).

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Starting mirtazapine tablets in a patient who is being treated with MAOIs such as linezolid or intravenous methylene blue is also contraindicated because of an increased risk of serotonin syndrome (see WARNINGS and DOSAGE AND ADMINISTRATION).

On rare occasions serotonin syndrome has occurred in association with treatment of mirtazapine tablets, particularly when given in combination with other serotonergic drugs.

Furthermore, very low incidences of clinically relevant changes in laboratory indices, such as the liver enzymes alanine aminotransferase and aspartate aminotransferase or neutropenia, were recorded in each treatment group.

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This monograph has been modified to include the generic and brand name in many instances.

Patients with liver or kidney disease should receive a reduced dose of mirtazapine or a reduction in the dosing schedule as discussed above.

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Mirtazapine Tablets and other antidepressant medicines may increase suicidal thoughts or actions in some children, teenagers, or young adults within the first few months of treatment or when the dose is changed.

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As with all drugs, knowledge of the in vitro pharmacology of mirtazapine can help us understand its clinical pharmacology.

New indications for selective serotonin reuptake inhibitors include post-traumatic stress disorder, premenstrual dysphoric disorder, and generalized anxiety disorder.

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Effects of selective serotonin reuptake inhibitors on platelet function: mechanisms, clinical outcomes and implications for use in elderly patients".

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Mirtazapine is a novel antidepressant in a new class referred to as the noradrenergic and specific serotonergic antidepressants.

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What Major Dimensions of Psychopathology Are Abnormal In Schizoaffective Disorder?

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The researchers stated that if SSRIs increase suicide risk in some patients, the number of additional deaths is very small because ecological studies have generally found that suicide mortality has declined (or at least not increased) as SSRI use has increased.

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Not only can a hypnotic potentially relieve the insomnia itself, but treating insomnia in patients with major depression may also increase remission rates due to improvement of other symptoms such as loss of energy and depressed mood.

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In terms of treatment, the medications used for Schizophrenia and Bipolar I Disorder are also used in Schizoaffective Disorder.

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Because of its different mechanism of action there is an argument that switching to mirtazapine alone after SSRI treatment failure might be an effective strategy, rather than subjecting patients to the potential adverse effect burden of a second medication.

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